قسم الكيمياء الحيوية السريرية

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من يعمل بـقسم الكيمياء الحيوية السريرية

يوجد بـقسم الكيمياء الحيوية السريرية أكثر من 7 عضو هيئة تدريس

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أ. حمزة سالم فرج عطية

منشورات مختارة

بعض المنشورات التي تم نشرها في قسم الكيمياء الحيوية السريرية

Comparative in-vitro Evaluation of Some Desloratadine Tablets Marketed in Tripoli Libya

Abstract Background and aims. Desloratadine is a tricyclic, potent, rapidly effective, long acting, non-sedative antihistamine, which has a selective and peripheral H1 receptor antagonist action, used to treat the allergies. The availability of several brands of Desloratadine tablets in Libyan pharmacies today places health practitioners and a pharmacist in a problem of drug substitution in case of a particular brand is not available. The aim of the present study was the evaluation and comparison of pharmaceutical equivalence of five different Desloratadine tablets 5 mg, which are commercially available in the private pharmacies in Tripoli city with different price ranges, produced by various pharmaceutical companies. Methods. The pharmaceutical evaluation of five brands of Desloratadine tablets were done using official and unofficial quality control tests prescribed in different Pharmacopoeia including uniformity of weight, thickness, hardness, disintegration time, drug content as well as dissolution rate and identification test. Acceptable external features as well as uniformity in diameter and thickness were revealed for all the tablets. Results. The entire selected brands complied with the official specifications for uniformity of weight, hardness and disintegration, more than 80% of their drug dissolved in the medium within 60 minutes. Conclusion. It can be concluded that all the brands could be regarded as bioequivalent and therefore can be interchanged in the clinical practice; this sort of study is good indicator for the evaluation of the idealness of commercial products and showed the importance of post marketing investigation for the drugs imported and distributed in Libya.
tamader youssef salem elghnimi, Wadiaa Abubaker Ali Ben Amer, Rehab Rmadan Ibrahim Walli(12-2022)
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Iron deficiency anemia in women in Zawia region

Iron deficiency anemia in women in Zawia region Hanan Thwer, Suhaela Twair, +1 author M. Abugila Published 2015 Medicine Anemia is a common health problem in women in developing countries, since anemia is more common in women than man due to physiological processes. This study was conducted in Zawia area and included 210 women in childbearing age (18-45 years) who were visiting Zawia teaching hospital. After filling the questionnaire, blood samples were taken and analyzed for hematological and biochemical profiles. Biochemical testes included measurement of serum iron, ferritin, and total-iron binding capacity. Among the total sample (210 women), there were 87 (41.4%) pregnant and 123 (58.6%) non-pregnant women (includes married and single). Pregnant women (87) were classified according to the gestational age into first, second, and third trimesters. Out of 87 pregnant women, there were 7 (8.04%) pregnant women in the first trimester, 34 (39.1%) in the second trimester, and 46 (52.9%) pregnant women in the third trimester. The means of biochemical and hematological parameters in the studied samples were: Hb = 10.37 ± 2.02 g/dl, RBC= 3.78 ± 1.037 m/m3, serum iron 61.86 ± 40.28 µg /dl, and TIBC = 386.01 ± 94.91 µg/dl. In this study, it is considered that any women have hemoglobin below 11.5 g/dl is anemic. 89.1%, 69.5%, and 47.8% of pregnant women who belong to third trimester had low (below normal value) Hb, serum iron, and ferritin, i.e. iron deficiency anemia was more common in third trimester among the first and the second trimesters. Third trimester pregnant women also had high TIBC more than first and second trimesters. We have compared between pregnant and non- pregnant women in the terms of hematological and biochemical parameters. We found that 85%, 65.3%, and 36.7% of pregnant women have low Hb, serum iron, and ferritin. This study showed that 45 (21.5%) out of 210 women (The whole samples) had iron deficiency anemia. i.e. 21.5% of women who included in this study in Zawia area had iron deficiency anemia. Among 45 women who have iron deficiency anemia, there were 30 (66.6%) pregnant, and 15 (33.3%) non-pregnant. That means prevalence of iron deficiency anemia was more in pregnant than non- pregnant as we expected. This study showed the effect of tea on absorption of iron. In this matter, drinking tea women in this study showed 42.4% a decrease in serum iron level. Collapse ljmr.com.ly
Mustafa Ali Abugila(1-2015)
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