قسم علم العقاقير والنواتج الطبيعية

المزيد ...

حول قسم علم العقاقير والنواتج الطبيعية

قسـم العقـاقير من ضمـن الأقسـام العلمية المتميزة والعريقة التي يتميـز بنشاطاته وحيويتـه فى مجال التخصص، ومنـذ نشأته في العام 1978م كان القسم مدموجاً مع قسم الكيمياء الطبية والصيدلية وفـى العـام 1986م تم فصله تحت اسم قسم العقاقير والنواتج الطبيعيـه وفي العـام 2000م تم تسميتـه قسـم العقاقير إلى الوقـت الحـالـي.قـام القسم بتنظيم العـديـد من الندوات العلميـة المتخصصة فى طرابلس أعوام 1999، 2000، 2004 فى إطار خطة مدروسة والمشاركة وتنظيم العـديد من الرحـلات العلمية للطــلاب لجمـع النباتات الطبية ومسحـها كيميائيـاً وبيولوجيــاً في منـاطق غدامــس والجبل الأخضـر والجبل الغـربي وتـرهـونـة وبني وليــد ومســلاته وأوبــارى فى الأعـوام 1983، 1984، 1985، 1987، 1990، 1992، 1997، 2000، 2001، 2002، 2004م ، ويقــوم القسم من خلال مجلسـه بتطـوير مناهجـه بيـن الحيـن والآخـر من خلال الأسـاتذة الـزوار والنظر إلى المنـاهج الحديثة بالأقسام المنـاظرة العربية والدولية، قـام القسـم بتــرشيح العـديد من المعيديـن والطاقـم التدريسي ومساعدي البحـاث والفنييـن في دورات تدريبيــه قصيرة، وتـم انشــاء الحديقة النبـاتيـة الطبية بالقسـم فى العـام 2003م للتعـرف عـلى الأصنـاف المختلفة من ناحية طرق زراعتها وشكلهـا الظـاهرى.

حقائق حول قسم علم العقاقير والنواتج الطبيعية

نفتخر بما نقدمه للمجتمع والعالم

43

المنشورات العلمية

10

هيئة التدريس

من يعمل بـقسم علم العقاقير والنواتج الطبيعية

يوجد بـقسم علم العقاقير والنواتج الطبيعية أكثر من 10 عضو هيئة تدريس

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أ. حنين نافذ محمد المغربي

حنين نافذ المغربي هي أحد أعضاء هيئة التدريس بقسم العقاقير والنواتج الطبيعية بكلية الصيدلة. تعمل حنين المغربي بجامعة طرابلس كـمحاضر مساعد منذ 23 سبتمبر 2019 ولها العديد من المنشورات العلمية في مجال تخصصها

منشورات مختارة

بعض المنشورات التي تم نشرها في قسم علم العقاقير والنواتج الطبيعية

Phytochemical Screening of Methanolic Extract of Five Libyan Date Varieties (Phoenix Dactylifera L.) And Evaluation of Their Antimicrobial Activity

More than 2000 cultivars of Phoenix dactylifera L. are known to grow around the world. Date is an essential fruit in North Africa, and in Libya in particular, it represents an important national food resource. Recently, researchers discovered the medicinal value of different parts of palm tree beside the well known nutritional value of the fruit edible part. In this study five Libyan date seeds (Bestian, Deglet, Abel, Khadrai and Hamrai) were collected from Aljofra region and were screened for phytochemical components and their antimicrobial activity. The phytochemical analysis of methanolic extract of five different Libyan date palm seeds showed the presence of aflavnoids, glycosides, phytosterols, phenolic compound, tannins, and fixed oil, absences of alkaloids and saponine. The susceptibility of bacterial species to five methanolic extracts of Phoenix dactylifera L seeds by cup-cut agar method exhibited Inhibition zones (IZD). That inhibition zone diameters are vary from 15.0 0.3 to 3.02 0.01 against MRSA; 16.040.1 to 6.0  0.7 against Pseudomonas aeruginosa; 14.2 0.1 to 6.00.7 against Proteus vulgaris; 18.3 0.2 to 6.0 0.1 against Staphylococcus aureus; 14.04 0.2 to 2.0 0.02 against E. coli; and 18.0 0.1 to3.2 0.02 against Klebsiella pneumonia. The results of current study shows the antibacterial properties of five Libyan samples of date seed extract against a wide spectrum of bacteria. arabic 21 English 126
Basma Doro, Nahla Labyad, Fadia Gafri(1-2020)
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Precursor-directed syntheses and biological evaluation of new elansolid derivatives

The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929. arabic 9 English 74
Heinrich Steinmetz, Wiebke Zander, Muftah A. M. Shushni, Rolf Jansen, Klaus Gerth, Richard Dehn, Gerald Dräger, Andreas Kirschning, Rolf Müller(8-2012)
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Phytochemical, Antioxidant, Antibacterial and Nutritional value of Cucurbita maxima D (Cucurbitaceae) grown in Tripoli– Libya

ABSTRACT Pumpkin (Cucurbita maxima D.) is an angiosperm belonging to the Cucurbitaceae family generally characterized by climbing herbaceous vine with tendrils. The fruits vary in size, colour, shape and weight and have a moderately hard rind, with a thick edible flesh, and numerous seeds in the fruit which are either plump and tan or soft white.Preliminary phytochemical evaluation on different extracts of seed and fruit of C.maxima reveals the presence of proteins, carbohydrates, flavonoids, saponins, alkaloids, steroids, coumerins, phenolic compounds, terpenoids, and glycosides. A C.maximum contains antioxidants (such as: tocopherols, flavonoids, and phenolic acids, carotenoids or ascorbic acid) which are molecule that are capable of slowing or preventing the oxidation of other molecules. They may protect cells from damage caused by unstable molecules known as free radicals. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions by being oxidized themselves.Free radical scavenging or antioxidant activity of the extract was determined on the basis of their scavenging activity of the stable 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical. Antibacterial activity of the crude extract was determined by Cup-cut agar diffusion method.The pulp and seed extracts showed significant antioxidant activity in a dose-dependent manner with good IC50 values. For the pulp IC50(s) were 4.25 ± 0.05, 3.84 ± 1.18 and 4.12 ± 0.32 for petroleum ether, chloroform and Methanol extracts, respectively. In addition the the seed IC50(s) were 9.22 ± 0.20, 14.5 ± 0.14 and 5.97 ± 1.70 for petroleum ether, chloroform and Methanol extracts, respectively. C.maxima extracts contains antioxidants that prevent the oxidative damage to DNA in presence of DNA damaging agent (Sybr Gold) at a high concentration. The percentage of hydroxyl radical scavenging activity of C. maxima determines the ability of antioxidant to scavenge the hydroxyl radicals. The antioxidant activity of C. maxima extracts has high scavenging activity (thermodynamic property) and relatively high reaction rate (kinetic property); therefore, the second order rate constant (ks) of the H-atom transfer from antioxidant to the hydroxyl radical was seen. The seed extract showed antibacterial properties on both Gram- positive and Gram-negative bacteria used in this study. This means that C. maxima are useful as potential antibacterial agents. It was also observed from this study, the variations in the antibacterial activities of the C. maxima may be due to the differences in their bioactive compositions or concentrations. In conclusion, the physicochemical and preliminary phytochemical evaluation of fruit and seeds of C.maxima provide valuable information regarding their identification, authentication and chemical constituents which may be useful for the standardization and preparation of medicinal plants. The constituents of fruit and seeds of C. maxima may have several medicinal properties and can be utilized for the treatment of various diseases. Further research on this species in Libya may help in the isolation of therapeutically potent compounds which can be finally be subjected to pharmacological activities, thus leading to opening up new avenues in the use of natural products for therapeutic purpose.
إيناس عبدالله السعداوي (2016)
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